Continuous Positive Airway Pressure Improves Quality of Life in Women with OSA. A Randomized-controlled Trial

Campos-Rodriguez F, Queipo-Corona C, Carmona-Bernal C, Jurado-Gamez B, Cordero-Guevara J5, Reyes-Nuñez N, Troncoso-Acevedo F, Abad-Fernandez A, Teran-Santos J, Caballero-Rodriguez J, Martin-Romero M, Encabo-Motiño A, Sacristan-Bou L, Navarro-Esteva J, Somoza-Gonzalez M, Masa JF, Sanchez-Quiroga MA, Jara-Chinarro B, Orosa-Bertol B, Martinez-Garcia MA; Spanish Sleep Network. Am J Respir Crit Care Med. 2016 May 15.

RATIONALE: Continuous positive airway pressure (CPAP) is the treatment of choice in patients with symptomatic obstructive sleep apnea (OSA). CPAP improves quality of life (QoL) in men with OSA but its role in women has not yet been assessed. OBJECTIVE: To investigate the effect of CPAP on QoL in women with moderate-to-severe OSA. METHODS: Multicenter, open-label, randomized controlled trial conducted in 307 consecutive women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ≥15) in 19 Spanish Sleep Units. Women were randomized to receive effective CPAP (n=151) or conservative treatment (n=156) for 3 months. The primary endpoint was the change in QoL using the Quebec Sleep Questionnaire (QSQ). Secondary endpoints included changes in daytime sleepiness, mood state, anxiety and depression. Data were analyzed on an intention-to-treat basis with adjustment for baseline values and other relevant clinical variables. RESULTS: Women had a mean (SD) age of 57.1 (10.1) years, Epworth score of 9.8 (4.4) and 77.5% were postmenopausal. Compared with the control group, the CPAP group achieved a significantly greater improvement in all quality-of-life domains of the QSQ (adjusted treatment effect between 0.53 and 1.33; p<0.001 for all domains), daytime sleepiness (-2.92; p<0.001), mood state (-4.24; p=0.012), anxiety (-0.89; p=0.014), depression (-0.85; p=0.016), and the physical component summary of the SF-12 (2.78; p=0.003). CONCLUSIONS: In women with moderate-to-severe OSA, 3 months of CPAP therapy improved quality of life, mood state, anxiety and depressive symptoms, and daytime sleepiness, compared to conservative treatment.

Ventana Cientifica. Noviembre 2016. Artículo 191
Continuous Positive Airway Pressure Improves Quality of Life in Women with OSA. A Randomized-controlled Trial


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