Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea

Santamaria-Martos F, Benítez I, Girón C, Barbé F, Martínez-García MA, Hernández L, Montserrat JM, Nagore E, Martorell-Calatayud A, Campos-Rodriguez F, Corral J, Cabriada V, Abad J, Mediano O, Troncoso MF, Cano-Pumarega I, Gutierrez AMF, Diaz-Cambriles T, Somoza-Gonzalez M, Almendros I, Farre R, Gozal D, Sánchez-de-la-Torre M; on the behalf of The Spanish Sleep Network. Eur Respir J. 2018 Mar 8.

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Abstract

The goal of this study was to assess the relationship between the severity of OSA and the levels of carcinogenesis- and tumour growth-related biomarkers, in patients with cutaneous melanoma (CM).This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI); 0-5 events/h), mild-OSA (AHI; 5-15 events/h), and moderate to severe OSA (AHI>15 events/h). Enzyme-linked immunosorbent assays (ELISAs) were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (VEGF, IL8, ICAM-1, VCAM-1), and markers of tumour aggressiveness (S100B, MIA). A logistic model adjusted for age, sex and body mass index (BMI) was fitted to each biomarker, and the AHI served as the dependent variable.A total of 360 patients were included (52.2% male, median [IQR]; 55.5 [43.8-68.0] years, AHI of 8.55 [2.8-19.5] events/h). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: OR=2.07,p=0.021; moderate-severe OSA: OR=2.35,p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion.