Sleep disorder, chorea, and dementia associated with IgLON5 antibodies.

Simabukuro MM1, Sabater L1, Adoni T1, Cury RG1, Haddad MS1, Moreira CH1, Oliveira L1, Boaventura M1, Alves RC1, Azevedo Soster L1, Nitrini R1, Gaig C1, Santamaria J1, Dalmau J1, Graus F1. Neurol Neuroimmunol Neuroinflamm. 2015 Jul 23;2(4):e136. eCollection 2015.

A novel syndrome characterized by a distinctive sleep disorder accompanied by variable symptoms of brainstem involvement and a highly restricted haplotype was recently described in association with antibodies to a neuronal cell adhesion protein named IgLON5. Because of the symptoms and chronic disease progression, most of these patients are primarily seen by specialists in sleep and neurodegenerative disorders. Since the initial description of this encephalopathy in 2014, only 1 additional patient has been reported.1 In order to improve clinical recognition we report a new patient who presented with the characteristic sleep dysfunction and subsequently developed chorea.

Ventana Científica. Diciembre 2015. Artículo 54
Sleep disorder, chorea, and dementia associated with IgLON5 antibodies.

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